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KMID : 0614019890050010081
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Journal of Pharmaceutical Sciences (C.N.U.)
1989 Volume.5 No. 1 p.81 ~ p.84
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Acetylpanaxydol und Panaxydolchlorhydrin, zwei neue, gegen L1210-Zellen cytotoxische Polyine aus Koreanischem Ginseng
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Ahn Byung-Zun
Kim Shin-Il
Lee You-Hui
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Abstract
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Zwei neue gegen L1210-Zellen cytotoxisch wirksame Polyine wurden aus Koreanischer Ginseng-Wurzel isoliert. Es handelt sich um 3-Acetyloxy-9,10-epoxyheptadec-1-en-4,6-diin (Acetylpanaxydol, ED_50=0.52 ㎍/㎖) und 10-Chlor-3,9-dihydroxyheptadec-1-en-4,6-diin (Panaxydolchlorthydrin, ED_50=0.50 ㎍/㎖).
Acetylpanaxydol and Panaxydolchlorohydrin, Two New Poly-ynes from Korean Ginseng with Cytotoxic Activity against L1210 Cells
Two new polyines showing good cytotoxic activity against L1210 cells were isolated from Korean ginseng root. These were 3-acetyloxy-9,10-epoxy-heptadec-1-en-4,6-diyne(acetylpanaxydol, ED_50=0.52 ㎍/㎖) and 10-chloro-3,9-dihydroxyheptadec-1-en-4,6-diyne(Panaxydolchlorohydrin, ED_50=0.50 ㎍/㎖).
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